Office: 312 Harned Hall
Ph.D. Developmental Biology, Duke University
B.A. Biology, University of Texas
Statement of Research Interests
Embryonic axes form the framework upon which the animal body plan is built during development. Research in the Range lab deals with one of the fundamental questions in developmental biology - how signaling and transcriptional regulatory interactions pattern embryos along these axes during development. By combining molecular manipulations, high-throughput genome-wide assays, gene regulatory network analysis and classical embryology the lab hopes to understand the developmental events that regulate axis specification and patterning in deuterostome embryos, which include chordates, hemichordates, and echinoderms. Current projects in the lab examine how information from different Wnt signaling pathways is used to activate and repress the gene regulatory networks that pattern the neuroectoderm along the anterior-posterior axis in the echinoderm sea urchin embryo. The lab is also interested in using the information gained from the sea urchin embryo as the basis to examine the evolution of anterior-posterior neuroectoderm pattering in hemichordates and invertebrate chordates.
Range RC, Angerer RC, and Angerer LA. “Integration of canonical and non-canonical Wnt signaling patterns the neuroectoderm along the anterior-posterior axis of the sea urchin embryo”. PLoS Biology. 2013. 11(1): e1001467
Wei Z, Range R, Angerer R, and Angerer L. “Axial patterning interactions in the sea urchin embryo: suppression of nodal by Wnt1 signaling”. Development. 2012; 139(9): 1662-9.
Sethi AJ, Wikramanayake RM, Angerer RC, Range RC, and Angerer LA. “Sequential signaling crosstalk regulates endomesoderm segregation in sea urchin embryos”. Science. 2012; 335(6068): 590-593.
Range R and Lepage T. “Maternal Oct1/2 is required for Nodal and Vg1/Univin expression during dorsal-ventral axis specification in the sea urchin embryo”. Developmental Biology. 2011; 17(10): 1487-98.
Croce J, Range R, Wu S, Miranda E, Lhomond G, Chieh-fu Peng J, Lepage T and McClay, DR. “Wnt 6 activates endoderm in the sea urchin gene regulatory network”. Development. 2011; 138: 3297-3306.
Saudemont A, Haillot E, Mekpoh F, Bessodes N, Quirin M, Lapraz F, Duboc V, Röttinger E, Range R, Oisel A, Besnardeau L, Wincker P, and Lepage T. “Gene regulatory network analysis of ectoderm specification in an echinoderm reveals ancestral regulatory circuits regulating mouth formation and neural induction”. PLoS Genetics. 2010. 6(12): e1001259.